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Glioblastoma multiforme arising in the irradiated spinal cord of a rhesus monkey ( Macaca mulatta )
Author(s) -
Price R. E.,
Tinkey P. T.,
Leeds N. E.,
Hazle J. D.,
Langford L. A.,
Stephens L. C.,
Ang K. K.
Publication year - 1996
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1996.tb00206.x
Subject(s) - glioblastoma , spinal cord , pathology , rhesus macaque , biology , anatomy , medicine , neuroscience , cancer research , virology
An adult female rhesus monkey that had received 44.0 Gy of cobalt 60 radiation to 8 cm of the cervical and upper thoracic spinal cord approximately 2.8 years postirradiation developed a sudden onset of self‐mutilation and loss of function of the right arm followed progressively by loss of function of the left arm and terminally bilateral paresis of the legs. Histopathologic examination of the cervical spinal cord revealed a glioblastoma multiforme that extended from the cervical medullary junction to the sixth cervical vertebrae. Because of the infrequent occurrence of spontaneous neoplasia in rhesus monkeys and the location in the radiation field, the glioblastoma is believed to be radiation induced.