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The glomerular filtration rate, effective renal plasma flow, and renal blood flow in the adult male chacma baboon ( Papio ursinus )
Author(s) -
Evans J.P.,
Candy G.P.,
Veller M.G.,
Esser J.D.
Publication year - 1996
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1996.tb00033.x
Subject(s) - effective renal plasma flow , renal function , renal blood flow , baboon , filtration fraction , pah clearance , kidney , medicine , endocrinology , urology , chemistry
The radionuclide determination of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) has been validated in man, but not in the primate. GFR, ERPF, and renal blood flow (RBF) were measured in a group of 12 adult male chacma baboons using radiopharmaceuticals. GFR was determined using 99m technetium‐labelled diethylenetriamine‐pentacetic acid. ERPF was measured with 131 iodine‐labelled hippuran. RBF, body surface area, and kidney weights were calculated using standard formulae. GFR was 49 ± 11 ml/min and ERPF was 237.9 ± 54.2 ml/min. Calculated RBF was 430.7 ± 111.9 ml/min and 507.4 ± 138.4 ml/min/100g of renal tissue. The results are in agreement with those obtained using more laborious nonradioisotopic techniques such as para‐aminohippurate (PAH) and creatinine clearance and could serve as baseline normal values in the adult male chacma baboon.