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Uterine epithelioid leiomyosarcoma in a pig‐tailed macaque
Author(s) -
Birkebak T.A.,
Wang N.P.,
Weyhrich J.
Publication year - 1996
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1996.tb00030.x
Subject(s) - desmin , pathology , immunohistochemistry , biology , leiomyosarcoma , vimentin , epithelioid cell , anatomy , medicine
During ultrasonographic examination following spontaneous abortion, an approximately 6‐cm diameter mass of mixed echogenicity is detected in the uterine wall of a mature pig‐tailed macaque (Macaca nemestrina). Grossly, the mass is associated with the uterine fundus, multilobulate and tan with red‐black mottled foci on cut surface. Microscopically, the invasive mass is composed of poorly differentiated round cells arranged in sheets and bundles supported by a fine fibrous stroma. On immunohistochemical evaluation, neoplastic cells contain vimentin, desmin, muscle actin, and smooth muscle α‐actin antigens and do not react with antibodies to low and high molecular‐weight cytokeratins. Cell morphology and immunohistochemical results indicate a diagnosis of epithelioid leiomyosarcoma (clear cell variant).