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The value of primate models for studying human immunodeficiency virus pathogenesis
Author(s) -
Levy Jay A.
Publication year - 1996
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1996.tb00013.x
Subject(s) - human immunodeficiency virus (hiv) , pathogenesis , primate , virology , non human primate , simian immunodeficiency virus , value (mathematics) , biology , medicine , computational biology , immunology , evolutionary biology , computer science , neuroscience , machine learning
Research on human immunodeficiency virus (HIV) infection is compromised by the obvious limitation in having for study only virus‐infected individuals or those exposed to the virus. Steps involved in transmission or pathogenesis require planned experimentation. The identification of animal models of acquired immunodeficiency syndrome (AIDS) has therefore been helpful for evaluating phases of HIV pathogenesis. Of the seven subgenera of lentiviruses now recognized, two share the characteristics with HIV of a T cell tropism and the associated loss of CD4+ cells in the host associated with disease: the feline immunodeficiency virus (FIV) and the simian immunodeficiency virus (SIV) (Table 1). The other animal lentiviruses grow best in macrophages and their infection generally reflects clinical sequellae of infection of this cell type. This review addresses those features of SIV, HIV, and SHIV infections of non‐human primates that illustrate the importance of the animal models of AIDS.