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Simian varicella virus antibody response in experimental infection of African green monkeys
Author(s) -
Gray Wayne L.,
Gusick Nanette J.,
Fletcher Thomas M.,
Solke Kenneth F.
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00178.x
Subject(s) - virology , simian , african green monkey , virus , antibody response , antibody , biology , simian immunodeficiency virus , immunology
The humoral immune response to simian varicella virus (SVV) was investigated following primary and secondary experimental infection of African green monkeys. Neutralization and immunoprecipitation assays were used to determine antibody titers to SVV throughout the course of infection. The immune response to specific viral polypeptides was analyzed by immunoprecipitation analysis. The results demonstrate that the simian varicella model offers a useful approach to investigate immune mechanisms in human varicella zoster virus (VZV) infections.