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VCAM‐1 expression and leukocyte trafficking to the CNS occur early in infection with pathogenic isolates of SIV
Author(s) -
Sasseville Vito G.,
Lane Joan H.,
Walsh Dennis,
Ringler Douglas J.,
Lackner Andrew A.
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00157.x
Subject(s) - simian immunodeficiency virus , biology , central nervous system , virology , cell adhesion molecule , immunology , virus , neuroscience
This study reports on the endothelial expression of vascular cell adhesion molecule‐1 (VCAM‐1) in the central nervous system (CNS) early after experimental infection of rhesus monkeys ( Macaca mulatta ) with pathogenic and nonpathogenic simian immunodeficiency virus (SIV). Diffuse endothelial expression of VCAM‐1 was observed in the CNS in all animals receiving pathogenic SIV These findings demonstrate the rapidity with which pathogenic SIV is able to enter the CNS and induce endothelial cell activation.