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Origins of simian immunodeficiency virus infection in macaques at The New England Regional Primate Research Center
Author(s) -
Mansfield K.G.,
Lerche N.W.,
Gardner M.B.,
Lackner A.A.
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00156.x
Subject(s) - simian immunodeficiency virus , virology , primate , biology , simian , polymerase chain reaction , virus , human immunodeficiency virus (hiv) , african green monkey , macaque , genetics , gene , paleontology , neuroscience
A cohort of rhesus macaques ( Macaca mulatta ), obtained from the California Regional Primate Research Center (CRPRC) and necropsied in 1970–72 with lesions suggestive of simian immunodeficiency virus (SIV) infection, was identified at the New England Regional Primate Research Center (NERPRC). Polymerase chain reaction (PCR), DNA sequence analysis, and in situ hybridization were used to confirm the presence of SIV nucleic acids. This represents the earliest case of SIV infection at the NERPRC and suggests a common source for present day SIV isolates.