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Immunocytochemistry of Kaposi's sarcoma‐like tumor cells from pigtailed macaques with simian AIDS
Author(s) -
Tsai CheChung,
Wu Hainan,
Meng Fang
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00143.x
Subject(s) - desmin , pathology , sarcoma , immunocytochemistry , biology , actin , vascular smooth muscle , myofibroblast , macaque , smooth muscle tumor , cell culture , vimentin , leiomyosarcoma , medicine , microbiology and biotechnology , immunohistochemistry , smooth muscle , endocrinology , paleontology , genetics , fibrosis
Some macaques infected with SRV‐2 developed SAIDS and RF, a Kaposi's sarcoma (KS)‐like tumor. We investigated the immunophenotypic markers of this SAIDS‐associated retroperitoneal fibromatosis (RF). RF tumor is characterized by proliferation of spindle cells accompanying inflammatory cell infiltrates, fibroblasts, and endothelial cells. RF spindle cells in tumor tissues revealed several immunobiologic characteristics similar to vascular smooth‐muscle cells or myofibroblasts based on positive immunoreactivity of smooth‐muscle α‐actin and desmin. The majority of cultured RF spindle cells also expressed specific markers for vascular smooth muscle. These results suggest that the RF spindle cells are derived from vascular smooth‐muscle cells. Furthermore, RF tissues and cells were persistently infected with SRV‐2, which may play an important role in viral etiology of AIDS‐associated neoplasm in this macaque model.