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Presence of virion protein x (Vpx) of simian immunodeficiency virus SIV mac 251 in target cells in vivo
Author(s) -
Persidsky Yury,
Liska Vladimir,
Huss Thierry,
Gendrault JeanLouis,
Venet Alain,
Muchmore Elisabeth,
Traincard François,
Kirn André,
Aubertin AnneMarie
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00142.x
Subject(s) - simian immunodeficiency virus , in vivo , virology , lymph , biology , antibody , viral replication , immunohistochemistry , follicular dendritic cells , virus , immunology , immune system , t cell , pathology , medicine , antigen presenting cell , microbiology and biotechnology
Localization of virion‐associated protein x (Vpx) of SIV mac 251 was studied in lymph nodes and liver of six SIV mac ‐infected monkeys. Vpx was found associated with the network of follicular dendritic cells and macrophages in lymph nodes and/or livers from five out of six animals by immunohistochemistry. Although the humoral response to Vpx occurs in only 50% of the animals, the presence of Vpx in target cell or antibodies to Vpx in all the monkeys studied, suggests that Vpx may be necessary for viral replication in vivo .