Premium
A baboon ( Papio hamadryas ) model of insulin‐dependent diabetes
Author(s) -
Heffernan Scott,
Phippard Andrew,
Sinclair Alan,
McLennan Susan,
Hennessy Annemarie,
Gillin Adrian,
Horvath John,
Tiller David,
Yue Dennis,
Turtle John
Publication year - 1995
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1995.tb00141.x
Subject(s) - streptozocin , baboon , diabetes mellitus , metabolic control analysis , medicine , insulin , endocrinology , toxicity , streptozotocin
Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. Streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. Using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2–4 U/kg, it is possible to maintain a degree of metabolic control similar to that attained in patients.