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Early helper T‐cell dysfunction in simian immunodeficiency virus but not in human immunodeficiency virus type‐2‐infected macaques
Author(s) -
Dittmer Ulf,
Lüke Wolfgang,
StahlHennig Christiane,
Coulibaly Cheick,
Petry Harald,
Bodemer Walter,
Hunsmann Gerhard,
Voss Gerald
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00287.x
Subject(s) - simian immunodeficiency virus , virology , macaque , virus , immunodeficiency , biology , simian , immunology , rhesus macaque , t cell , african green monkey , immune system , paleontology
Both naive and vaccinated macaques acquired a virus‐specific proliferative helper T‐cell reactivity in response to infection with the nonpathogenic human immunodeficiency virus type 2 (HIV‐2). In contrast, macaques infected with the pathogenic simian immunodeficiency virus of the macaque strain (SIV mac ) did not develop a helper T‐cell response. Furthermore, a vaccine‐induced preexisting T‐cell reactivity was abrogated after SIV mac infection in vaccine failures. These differences may reflect the different pathogenicity of the two closely related viruses.