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Primate antibodies to components of the human immune system
Author(s) -
Lögdberg L.,
Kaplan E.,
Drelich M.,
Harfeldt E.,
Gunn H.,
Ehrlich P.,
Dottavio D.,
Lake P.,
Östberg L.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00286.x
Subject(s) - immune system , antibody , primate , monoclonal antibody , immunology , nonhuman primate , antigen , non human primate , biology , recombinant dna , virology , tumor necrosis factor alpha , cytokine , gene , genetics , neuroscience , evolutionary biology
The feasibility to raise nonhuman primate antibodies against selected components of the human immune system was tested. The immunogens were whole cells (human T lymphocytes) or purified, recombinant human proteins (cytokines: TNFα or GM‐CSF; soluble forms of cell surface antigens: sCD4 or sCD25). Significant immunizations, yielding functionally relevant antibodies, were readily achieved in rhesus monkeys, but, not surprisingly, may be less frequent in chimpanzees. The results suggest a general strategy for production of therapeutically useful MAB.