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A review of studies of the activation of the blood coagulation mechanism in chimpanzees ( Pan troglodytes )
Author(s) -
Cate Hugo,
Schenk B. Edwin,
Biemond Bart J.,
Levi Marcel,
Poll Tom,
Buller Harry R.,
Cate Jan W.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00285.x
Subject(s) - coagulation , fibrin , factor ix , tissue factor , factor x , factor vii , mechanism of action , coagulation system , immunology , platelet , medicine , biology , chemistry , thrombin , biochemistry , in vitro
This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa‐tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa‐TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines.