Premium
Histochemical and immunohistochemical similarities between hepatic tumors in two chimpanzees and man
Author(s) -
Tabor Edward,
Hsia Chu Chieh,
Muchmore Elizabeth
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00284.x
Subject(s) - immunohistochemistry , hccs , hepatocellular carcinoma , pathology , biology , positive staining , staining , cancer research , medicine
A well‐differentiated trabecular hepatocellular carcinoma (HCC) and a well‐differentiated tumor resembling HCC from each of two chimpanzees were found to have histochemical and immunohistochemical staining characteristics similar to those in human HCCs. Transforming growth factor α was overexpressed in both tumors. Oval cells, thought to be liver stem cell progeny with a possible role in hepatocarcinogenesis, were observed among nontumorous hepatocytes, particularly near the tumors. Hepatic tumors are rare in chimpanzees but their similarities to human HCC provides a useful research model.