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Intrarectal inoculation of macaques by the simian immunodeficiency virus, SIV mne E11S: CD4 + depletion and AIDS
Author(s) -
Kuller LaRene,
Benveniste Raoul E.,
Tsai CheChung,
Clark Edward A.,
Polacino Patricia,
Watanabe Robin,
Overbaugh Julie,
Katze Michael G.,
Morton William R.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00127.x
Subject(s) - simian immunodeficiency virus , macaca nemestrina , virology , clone (java method) , virus , biology , peripheral blood mononuclear cell , inoculation , simian , immunology , haplorhini , macaque , in vitro , dna , paleontology , biochemistry , genetics
Macaca nemestrina and Macaca fascicularis were inoculated with various doses of a single‐cell clone of SIV mne ‐infected HuT 78 cells (E11S) by both the intravenous and intrarectal routes. Animals inoculated intravenously at each dose seroconverted and virus was isolated from peripheral blood mononuclear cells, but only the high‐dose intrarectally exposed macaques became viremic and seroconverted. However, some seronegative, virus isolation negative intrarectally inoculated macaques showed evidence of infection and disease.