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Passive immunization of macaques against SIV infection
Author(s) -
Gardner Murray B.,
Rosenthal Ann,
Jennings Myra,
Yee JoAnn,
Antipa Linda,
MacKenzie Malcolm
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00118.x
Subject(s) - immunization , virology , asymptomatic , antibody , immunology , medicine , simian immunodeficiency virus , rhesus macaque , virus , biology
Passive immunization with plasma from an inactivated‐whole SIV mac vaccine protected monkey conferred complete or partial protection to rhesus macaques challenged intravenously 4 or 18 hours later with 10 AID 50 of homologous cell‐free virus. In contrast, passive immunization with inactivated plasma or purified immunoglobulin (Ig) from SIV mac infected asymptomatic monkeys failed to protect any recipients similarly challenged and may have enhanced infection and accelerated disease. Administered 24 hours post challenge, anti‐SIV Ig may also have enhanced the infection.