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Cell type‐dependence for Vpu function
Author(s) -
Geraghty Robert J.,
Talbot Katrin J.,
Callahan Michael,
Harper Wade,
Panganiban Antonito T.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00115.x
Subject(s) - hela , microbiology and biotechnology , virus , biology , function (biology) , virology , yeast , cell , genetics
Human immunodeficiency virus type 1 Vpu has been shown to facilitate virus release from HeLa cells. We demonstrated that Vpu expression is not required for efficient virus release from Cos 1 and CV‐1 cells. A yeast GAL4 transcriptional activation system was used to screen for cellular proteins that may interact with Vpu. One such protein was identified which we provisionally designate “Vpu interactive protein” or VIP.