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Viral genetic determinants in SIV smmPBj pathogenesis
Author(s) -
Novembre Francis J.,
Saucier M. Michelle,
Hirsch Vanessa M.,
Johnson Philip R.,
McClure Harold M.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00114.x
Subject(s) - biology , simian immunodeficiency virus , genome , virology , gene , lentivirus , disease , virus , macaca nemestrina , genetics , pathogenesis , simian , viral disease , immunology , macaque , medicine , paleontology , pathology
A variant simian immunodeficiency virus (SIV) from sooty mangabeys, SIV smmPBj , induces an acutely lethal disease in pigtailed macaques ( Macaca nemestrina ). This study further characterizes the viral genetic determinants involved in this acutely lethal disease. We have generated chimeric molecular clones constructed between SIV smmPBj and either SIV smH4 or SIV smm9 to analyze the role of the 5′ half of the genome and the envelope gene in the induction of acute disease. These studies suggest that the gag and gp40 of SIV smmPBj are required for the development of lethal disease, and an additional determinant in the central regulatory gene region of the SIV smmPBj genome is also required.