TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates | Zendy

Ansari Aftab A. | Zendy; Mayne Ann | Zendy; Hunt Dirk | Zendy; Sundstrom J. Bruce | Zendy; Villinger Francois | Zendy

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TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates

Author(s) -

Ansari Aftab A.,

Mayne Ann,

Hunt Dirk,

Sundstrom J. Bruce,

Villinger Francois

Publication year - 1994

Publication title -

journal of medical primatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 42

eISSN - 1600-0684

pISSN - 0047-2565

DOI - 10.1111/j.1600-0684.1994.tb00109.x

Subject(s) - biology , macaque , nonhuman primate , peripheral blood mononuclear cell , cd8 , rhesus macaque , cytokine , t cell , primate , immunology , microbiology and biotechnology , cell culture , in vitro , virology , genetics , immune system , evolutionary biology , neuroscience

Cloned T‐cell lines from two nonhuman primate species were phenotyped and their mRNA analyzed for cytokine profiles by RT‐PCR procedures. PBMC from rhesus macaques showed a relatively high frequency of cloned T‐cell lines with a TH1‐like profile; PBMC from sooty mangabeys showed a relatively high frequency of TH2‐like cloned T‐cell lines. In vitro activated macaque PBMC also resulted in a high frequency of CD4 + , CD8 + dual marked cells. These findings suggest that cytokine analysis of cloned T‐cell lines from nonhuman primates provides a means to distinguish subsets of both CD4 + and CD8 + T cells.

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