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Mucosal immunization with a live, virulence‐attenuated simian immunodeficiency virus (SIV) vaccine elicits antiviral cytotoxic T lymphocytes and antibodies in rhesus macaques
Author(s) -
Lohman Barbara L.,
McChesney Micheal B.,
Miller Christopher J.,
Otsyula Moses,
Berardi Christopher J.,
Marthas Marta L.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00108.x
Subject(s) - simian immunodeficiency virus , virology , immunization , cytotoxic t cell , immunology , ctl* , biology , antibody , immunity , virus , attenuated vaccine , immune system , virulence , cd8 , biochemistry , in vitro , gene
An effective AIDS vaccine must protect against sexual transmission of human immunodeficiency virus (HIV). Therefore, vaccine regimens which stimulate antiviral immunity in the genital tract as well as in peripheral blood and systemic lymphoid tissues are needed. Here, we describe a method of immunization by direct inoculation of the vaginal submucosa with a live attenuated SIV, SIV mac1A11 . Immunization by this route generated low levels of SIV‐specific IgG and IgA antibodies in serum and vaginal secretions and viral specific cytotoxic T lymphocyte (CTL) activity in peripheral blood.