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Efficacy of inactivated whole HIV‐2 vaccines with various adjuvants in cynomolgus monkeys
Author(s) -
Putkonen Per,
Nilsson Charlotta,
Walther Lilian,
Ghavamzadeh Lili,
Hild Kerstin,
Broliden Kristina,
Biberfeld Gunnel,
Thorstensson Rigmor
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00107.x
Subject(s) - virology , adjuvant , immunization , antibody , virus , titer , immunology , neutralizing antibody , antibody dependent cell mediated cytotoxicity , biology , medicine , vaccination , homologous chromosome , monoclonal antibody , biochemistry , gene
Twenty‐one cynomolgus monkeys were immunized with whole inactivated HIV‐2 preparations administered with various adjuvants (incomplete Freund's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID 50 of a homologous monkey‐cell grown, cell‐free HIV‐2. Seven animals were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibodies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous challenge with a monkey‐cell grown cell‐free human immunodeficiency virus type 2.