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Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques ( Macaca mulatta )
Author(s) -
Benveniste R.E.,
Roodman S.T.,
Hill R.W.,
Knott W.B.,
Ribas J.L.,
Lewis M.G.,
Eddy G.A.
Publication year - 1994
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1994.tb00106.x
Subject(s) - simian immunodeficiency virus , infectivity , virology , clone (java method) , biology , inoculation , virus , immunology , genetics , dna
The macaque infectious dose (MID) of a single‐cell clone of simian immunodeficiency virus isolated from a pig‐tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques ( Macaca mulatta ). Twenty‐one macaques were inoculated with 10‐fold dilutions of the virus stock (three or four animals per dose). The virologic and clinical status of these animals was monitored for 26 weeks. The 25% MID (MID 25 ) occurred at a 10 5 ‐fold dilution of the viral stock.