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Viral persistence of simian type D retrovirus (SRV‐2/W) in naturally infected pigtailed macaques ( Macaca nemestrina )
Author(s) -
Moazed Teresa C.,
Thouless Margaret E.
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00690.x
Subject(s) - macaca nemestrina , virology , biology , persistence (discontinuity) , retrovirus , simian , macaque , nonhuman primate , virus , paleontology , geotechnical engineering , engineering , evolutionary biology
To elucidate sites of SRV‐2/W persistence, tissue DNA from three groups of naturally infected Macaca nemestrina was analyzed for provirus: vertically transmitted, viremic, seronegative macaques; horizontally transmitted, viremic, seronegative macaques, and nonviremic seropositive macaques. In viremic animals infected vertically, provirus was found in many tissues, whereas in those infected horizontally, proviral DNA was limited. In V–Ab+ macaques, provirus was detected in bone marrow and/or ileocecal junction, confirming the presence of provirus in V –Ab+ animals.