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Characterization of monoclonal antibodies to the envelope proteins of an immunodeficiency virus of African green monkeys, SIV agmTYO‐7
Author(s) -
Otteken Ahlert,
Nick Sigrid,
Bergter Wolfgang,
Lüke Wolfgang,
StahlHennig Christiane,
Peters J. Hinrich,
Voss Gerald,
Hunsmann Gerhard
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00667.x
Subject(s) - epitope , simian immunodeficiency virus , virology , monoclonal antibody , gp41 , biology , virus , viral envelope , antibody , transmembrane protein , immunology , genetics , receptor
Five monoclonal antibodies (mabs) specific for the envelope proteins of a simian immunodeficiency virus of African green monkeys (SIV agm ) have been raised. Two mabs were directed against distinct epitopes on the transmembrane protein gp41. A conformational epitope on the gp130 was recognized by three mabs. This is the first report on mabs specific for SIV agm‐gp130 . Studies of the cross‐reactivities revealed that the epitopes recognized by the env‐directed mabs are conserved species‐specifically in SIV agm isolates. Therefore, these mabs can be used to distinguish SIV agm strains from other virus groups.