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The resistance of HIV‐infected chimpanzees to progression to AIDS correlates with absence of HIV‐related T‐cell dysfunction
Author(s) -
Heeney Jonathan,
Jonker Richard,
Koornstra Wim,
Dubbes Rob,
Niphuis Henk,
Di Rienzo AnnaMarie,
Gougeon MarieUse,
Montagnier Luc
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00659.x
Subject(s) - asymptomatic , immunology , human immunodeficiency virus (hiv) , in vitro , virology , biology , t cell , programmed cell death , in vivo , immunopathology , medicine , immune system , apoptosis , genetics
Differences in the in vivo and in vitro responses of T lymphocytes from chimpanzees and human subjects were compared for evidence of HIV‐1 related T‐cell dysfunction. There was no increased level of programmed cell death (PCD) in HIV‐1 infected chimpanzees in contrast to asymptomatic individuals. Anergy could be induced with HIV‐1 gp120 in human but not chimpanzee T H lymphocytes, however in vitro infection of chimpanzee T H cultures with HIV‐1 resulted in complete lysis of cells within three weeks. These findings suggest that the resistance of HIV‐1 infected chimpanzees to progression to AIDS is due to their relative resistance to the systemic effects of HIV‐1 on T‐cell dysfunction.