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Pathogenesis of SIV mac251 after atraumatic inoculation of the rectal mucosa in rhesus monkeys
Author(s) -
Pauza C. David,
Emau Peter,
Salvato Maria S.,
Trivedi Parul,
MacKenzie Debra,
Malkovsky Miroslav,
Uno Hideo,
Schultz Kevin T.
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00654.x
Subject(s) - simian immunodeficiency virus , pathogenesis , inoculation , antibody , medicine , blood transfusion , virology , virus , biology , immunology
Intrarectal inoculation of rhesus monkeys with low doses of SIV mac led to a prolonged clinical and virological latency that was not observed for high intrarectal doses or for intravenous inoculation. Animals infected intrarectally with low virus doses remained negative for serum antibody responses to SIV for at least one year even though they readily transferred SIV to naive recipients via transfusion of whole blood.