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Dynamics of the immune system response in cerebrospinal fluid and blood of SIV mac ‐infected rhesus monkeys
Author(s) -
Sopper Sieghart,
Hemm Susanne,
Meixensberger Jürgen,
Coulibaly Cheik,
StahlHennig Christiane,
Hunsmann Gerhard,
Fleckenstein Bernhard,
Meulen Volker ter,
Dörries Rüdiger
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00652.x
Subject(s) - antibody , virology , titer , cerebrospinal fluid , immune system , biology , virus , immunology , cd8 , simian immunodeficiency virus , specific antibody , antibody titer , neuroscience
Paired sera and CSF samples were collected from SIV mac ‐infected macaques. Animals infected with SIV mac251 maintained low gag and high env‐specific antibody levels in plasma. Increasing env‐specific antibody titers in CSF were associated in one animal with strong intrathecal synthesis. SIV mac239 ‐infected monkeys revealed high antibody titers of gag and env‐specificity, in one animal accompanied by weak intrathecal synthesis of virus‐specific antibodies. In all animals, the CD4/CD8 ratio in CSF decreased faster compared to blood.