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SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques
Author(s) -
Torres José V.,
Anderson David E.,
Malley Arthur,
Banapour Babak,
Axthelm Michael K.,
Benjamini Eli,
Gardner Murray B.
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00651.x
Subject(s) - epitope , virology , glycoprotein , antibody , neutralization , biology , neutralizing antibody , immunology , microbiology and biotechnology
We analyzed SIV‐specific monkey sera to localize B‐cell epitopes of the envelope glycoprotein of SIV (gp130), using overlapping synthetic peptides representing the entire SIV gp130 protein and sera from experimentally infected monkeys and monkeys immunized with whole, inactivated SIV. A B‐cell epitope which induces neutralizing antibody production and T‐cell responses was characterized as well as a new B‐cell epitope and a previously described neutralizing epitopes. Vaccinated monkey sera recognize the three epitopes differentially relative to unimmunized controls, and a correlation appears to exist between degree of cross‐neutralization by infected monkey sera and degree of binding to these three regions.