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Whole inactivated SIV vaccine grown on human cells fails to protect against homologous SIV grown on simian cells
Author(s) -
Putkonen Per,
Nilsson Charlotta,
Hild Kerstin,
Benthin Reinhold,
Cranage Martin,
Aubertin Anne Marie,
Biberfeld Gunnel
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00646.x
Subject(s) - simian immunodeficiency virus , virology , homologous chromosome , rhesus macaque , biology , macaque , virus , simian , haplorhini , gene , genetics , paleontology
Several groups have reported protection against experimental SIV infection in macaques immunized with a whole inactivated virus vaccine. The aim of the current study was to investigate whether five macaques vaccinated with whole inactivated SIV and previously shown to be protected against challenge with two divergent strains of SIV grown on human cells could resist challenge with a subsequent homologous SIV grown on macaque cells. We show here that this same vaccine did not protect when the challenge virus was grown on primary cells of monkey origin.