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Recent advances in molecular and genetic analysis of Rh blood group structures
Author(s) -
Colin Yves,
CherifZahar Baya,
Le Van Kim Caroline,
Mouro Isabelle,
Cartron JeanPierre
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00634.x
Subject(s) - gene , gene duplication , rh blood group system , biology , locus (genetics) , genetics , homology (biology) , rna splicing , genome , sequence analysis , alternative splicing , microbiology and biotechnology , antibody , messenger rna , rna
The Rh antigens are carried by 30‐32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD , which encodes the major D antigen and is present only in Rh‐positive genomes, and RhCcEe , which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non‐D Rh mRNAs have been cloned. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.