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Relationship between chimpanzee Rh‐like genes and the R‐C‐E‐F blood group system
Author(s) -
Salvignol I.,
Blancher A.,
Calvas P.,
Socha W.W.,
Colin Y.,
Cartron J.P.,
Ruffié J.
Publication year - 1993
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1993.tb00632.x
Subject(s) - complementary dna , gene , biology , genomic dna , exon , phenotype , southern blot , genetics , microbiology and biotechnology , restriction enzyme , polymorphism (computer science) , allele
The antigenic closeness between the chimpanzee alloantigen R c of the R‐C‐E‐F system, and the human alloantigen Rh o (D) suggests a phylogeconnection between their genes. To confirm at the molecular level the common origin of these genes, genomic DNA from 16 unrelated chimpanzees of various R‐C‐E‐F phenotypes were digested by three restriction enzymes and analyzed by Southern blot using a human Rh cDNA probe and three exon‐specific probes. Restrictions profiles displayed reach polymorphism. Correlations between some bands and certain R‐C‐E‐F phenotypes demonstrate that the human Rh cDNA probe defines in chimpanzee genomic DNA some genes of the R‐C‐E‐F system.