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Establishment and characterization of Macaca fascicularis lymphoblastoid cell lines
Author(s) -
Manning Carolina H.,
Heise Eugene R.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00620.x
Subject(s) - biology , major histocompatibility complex , virology , peripheral blood mononuclear cell , macaque , virus , flow cytometry , cell culture , mhc class i , epstein–barr virus , microbiology and biotechnology , immunology , antigen , genetics , in vitro , paleontology
A panel of cynomolgus macaque lymphoblastoid cell lines (LCL) was established by transforming peripheral blood mononuclear cells (PBMC) with Herpesvirus papio (HVP), and selected lines were examined by flow cytometry. Results indicate that HVP‐transformed macaque LCL are phenotypically heterogeneous and resemble human Epstein‐Barr virus (EBV)‐transformed LCL in the abundant expression of major histocompatibility complex (MHC) class I and class II molecules. At least some lines are of B cell origin.