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Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys: I. Effect of pentoxifylline on neutrophil influx
Author(s) -
Cheung Anthony T.W.,
Moss Richard B.,
Leong Albin B.,
Novick William J.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00604.x
Subject(s) - pentoxifylline , pseudomonas aeruginosa , microbiology and biotechnology , biology , medicine , immunology , pharmacology , bacteria , genetics
Host defense abnormalities in cystic fibrosis (CF) against Pseudomonas aeruginosa (PA) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. We have developed a rhesus monkey model of chronic PA endobronchitis by intrabronchial instillation of PA‐embedded agar beads, utilizing flexible fiberoptic bronchoscopy. Treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. The results suggest a method by which neutrophil influx and pulmonary damage in CF patients can be managed or prevented.