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Is preoperative fasting necessary?
Author(s) -
Popilskis Sulli,
Danilo Peter,
Acosta Harry,
Kohn Dennis
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00602.x
Subject(s) - cimetidine , ranitidine , medicine , anesthesia , histamine , gastric fluid , residual volume , gastric content , volume (thermodynamics) , gastric secretion , stomach , gastroenterology , chemistry , chromatography , lung volumes , physics , lung , quantum mechanics
The effects of fasting and of histamine (H 2 ) antagonists on gastric volume and acidity were studied in 56 baboons undergoing various surgical procedures under general anesthesia and randomly allocated into 4 groups; group A—fasted for 14 hours; group B—given 100‐120 ml of water 3 hours before surgery; groups C and D—also given 100‐120 ml of water 3 hours before surgery; in addition, the former received cimetidine 10 mg/kg IM and the latter ranitidine 1.5 mg/kg IM 30‐40 minutes before anesthesia. There were no significant differences between groups A and B with respect to the gastric volume and pH. Both ranitidine and cimetidine significantly ( P < 0.02) reduced gastric volume and increased gastric pH. Thus, prolonged withholding of oral fluids does not reduce the gastric volume or increase gastric pH. H 2 ‐antagonists are effective in reducing both gastric residual volume and pH.