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Identification of two subclasses of IgA in the chimpanzee ( Pan troglodytes )
Author(s) -
Cole Michael F.,
Hale Cynthia A.,
Sturzenegger Susi
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00591.x
Subject(s) - jacalin , protease , galactose , troglodytes , immunoglobulin a , lectin , chemistry , antibody , biology , biochemistry , immunology , immunoglobulin g , zoology , enzyme
Chimpanzee secretory immunoglobulin A (SIgA) was separated into two fractions by chromatography using the terminal galactose‐binding lectin Jacalin. The SIgA fraction bound by Jacalin was cleaved by Haemophilus influenzae IgA1 protease, whereas the SIgA nonbinding fraction was not cleaved. It is proposed that these fractions represent IgA1 and IgA2 subclasses because the presence or absence of galactose‐terminal oligosaccharides (Jacalin binding) and susceptibility or resistance to IgA1 protease are properties that define human IgA1 and IgA2 subclasses.