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The baboon model under anesthesia for in vivo cerebral blood flow studies using single photon emission computed tomographic (SPECT) techniques
Author(s) -
Dormehl Irene,
Redelinghuys Friedrich,
Hugo Niek,
Oliver Douglas,
Pilloy Wilfred
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00590.x
Subject(s) - baboon , cerebral blood flow , anesthetic , anesthesia , single photon emission computed tomography , halothane , ketamine , medicine , in vivo , emission computed tomography , blood flow , pentobarbital , nuclear medicine , positron emission tomography , cardiology , biology , microbiology and biotechnology
Single photon emission computed tomography of the brain can be useful in animal experimentation directed toward cerebral conditions. A well established and understood baboon model, necessarily under anesthesia, could be especially valuable in such investigations. Six normal baboons were studied under various anesthetic agents and their combinations: ketamine, thiopentone, pentobarbitone, and halothane. Cerebral blood flow (CBF) studies were performed with 99m Tc‐HMPAO. CBF effects from various anesthesia were detected, requiring careful choice of the anesthesia for cerebral investigations.