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Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates
Author(s) -
Higgins Joanne R.,
Sutjipto Suganto,
Marx Preston A.,
Pedersen Niels C.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00589.x
Subject(s) - simian immunodeficiency virus , epitope , virology , biology , monoclonal antibody , macaque , simian , antigen , group specific antigen , virus , antibody , immunology , paleontology
Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV‐1 IIIb , HIV‐2 R0D , and SIV isolates from macaque (SIV mac ), sooty mangabey (SIV sm ‐UCD), African green monkey (SIV agra ), and stump‐tailed macaque (SIV stm ‐UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.