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Worldwide survey of AIDS vaccine challenge studies in nonhuman primates: Vaccines associated with active and passive immune protection from live virus challenge
Author(s) -
Warren Jonathan T.,
Dolatshahi Mariam
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00581.x
Subject(s) - medicine , immunization , macaque , immunology , human immunodeficiency virus (hiv) , nonhuman primate , hiv vaccine , vaccination , virology , immune system , clinical trial , rhesus macaque , biology , vaccine trial , neuroscience , pathology , evolutionary biology
An AIDS Vaccine Surveillance System (AVSS) was designed and implemented to track the rapidly growing international database supporting the development of promising AIDS vaccines. Both preclinical nonhuman primate (NHP) and clinical human trials are tracked by the AVSS. This report presents summary data generated from the AVSS on the NHP AIDS vaccine/live virus challenge studies only. Summary data on more than 100 preclinical HIV/SIV vaccines are presented within the framework of 1) 13 arbitrary Vaccine Types, 2) studies grouped by animal model (i.e.. chimpanzee/HIV‐1, and macaque/SIV, H1V‐2), and 3) immunization approach (i.e., active and passive). Systematic and timely presentations of these summary data, both here and in future reports, aim to promote a clearer understanding of both earlier and more recent preclinical AIDS vaccine developments.