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Vaccination of pregnant cynomolgus monkeys with whole formalin‐inactivated SIV mac251
Author(s) -
Titti F.,
Borsetti A.,
Geraci A.,
Sernicola L.,
Giuseppini L.,
Turillazzi G.P.,
Pace M.,
Baroncelli S.,
Amadori A.,
Giovannetti A.,
Dianzani F.,
ChiecoBianchi L.,
Rossi G.B.,
Verani P.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00573.x
Subject(s) - simian immunodeficiency virus , virology , immunization , antibody , vaccination , simian , offspring , immunology , pregnancy , virus , medicine , biology , genetics
Five pregnant (two to three and one‐half months) Macaca fascicularis seroconverted following immunization with sucrose‐gradient purified and formalin‐inactivated whole simian immunodeficiency virus (SIV mac251 ). No untoward effects on fetal maturation were observed during the immunization of the mothers. Antibodies to SIV mac251 (also those with in vitro neutralizing activity) were passively transferred to the offspring but disappeared within two to six months after birth. Antibodies to env glycoprotein (gp130) lasted longer than those against viral gag proteins (p26,p60).