Premium
Characterization of group specific antibodies in primates: Studies with SIV envelope in macaques
Author(s) -
Haigwood Nancy L.,
Misher Lynda,
Chin S. Michael,
Blair Margaret,
Planelles Vicente,
Scandella Carl J.,
Steimer Kathelyn S.,
Gardner Murray B.,
Yilma Tilahun,
Hirsch Vanessa M.,
Johnson Philip R.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00572.x
Subject(s) - virology , antibody , simian immunodeficiency virus , biology , virus , group a , viral envelope , envelope (radar) , primate , immunology , medicine , telecommunications , radar , computer science , neuroscience
Sera from SIV‐infected macaques were found to contain antibodies that reacted with conformation‐dependent, group‐specific determinants on the SIV envelope protein gp130. These conformation‐dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV‐infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.