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Correlates of SIV encephalitis in rhesus monkeys
Author(s) -
Baskin Gary B.,
MurpheyCorb Michael,
Roberts E. Donald,
Didier Peter J.,
Martin Louis N.
Publication year - 1992
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1992.tb00568.x
Subject(s) - encephalitis , virology , viral encephalitis , simian immunodeficiency virus , virus , biology , immunology , incidence (geometry) , medicine , physics , optics
Necropsy records from 204 SIV‐infected rhesus monkeys that had been inoculated with various strains of SIV and had died of SIV‐related disease were reviewed. The relationship of SIV encephalitis with other parameters was evaluated. Encephalitis was associated with the presence of syncytial cells in other tissues, with persistent or early recurrent antigenemia, with a selective decrease in CD4 + CD29 + blood lymphocytes, and with a shortened time of survival. Monkeys whose lymphocytes produced high levels of virus in culture also had a higher incidence of encephalitis. SIV was more frequently isolated from the brains of animals with encephalitis. No other clear associations were detected.