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Neutralization epitope in the envelope glycoprotein of simian retrovirus‐1 (SRV‐1) and identification of the virus receptor
Author(s) -
Torres José V.,
Werner Linda L.,
Malley Arthur,
Benjamini Eli
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00522.x
Subject(s) - virology , immunoprecipitation , epitope , glycoprotein , viral envelope , biology , retrovirus , antibody , neutralization , virus , microbiology and biotechnology , neutralizing antibody , monoclonal antibody , immunology
We previously demonstrated that the area encompassing residues 147–162 of the envelope protein of simian retrovirus serotype‐1 (SRV‐1) is the target for rhesus anti‐SRV‐1 neutralizing antibodies. A peptide representing amino acids 142–167 of envelope protein (gp70) is capable of inducing virus‐neutralizing antibodies in mice. The virus receptor was immunoprecipitated from Raji cells using gp70 as the ligand. Antibodies to peptide 142–167 inhibit the immunoprecipitation, indicating that the receptor recognizes residues 142–167 of the viral envelope protein.