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Serial pathogenesis study of SIV brain infection
Author(s) -
Sharer Leroy R.,
Michaels Jennifer,
MurpheyCorb Michael,
Hu FuSen,
Kuebler Dorothy J.,
Martin Louis N.,
Baskin Gary B.
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00521.x
Subject(s) - leptomeninges , parenchyma , pathogenesis , pathology , white matter , encephalitis , medicine , disease , immunology , biology , virology , central nervous system , virus , magnetic resonance imaging , radiology
A serial study of early SIV brain infection revealed initial involvement of leptomeninges, followed by perivascular infection of brain parenchyma. Severity of SIV encephalitis correlated with severity of systemic disease rather than with length of infection. Diffuse white matter disease was not observed, and there was little evidence of SIV infection of brain endothelial cells. SIV infection of leptomeninges is separate from infection of the brain, which appears to be due to transvascular spread of infected monocytes/macrophages.