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Interleukin‐6 and retroperitoneal fibromatosis from SRV‐2–infected macaques with simian AIDS
Author(s) -
Roodman Stanford T.,
Woon Ming Dar,
Hoffmann Joseph W.,
Theodorakis Paul,
Tsai Cheng C.,
Wu HN,
Tsai CheChung
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00519.x
Subject(s) - autocrine signalling , simian , biology , cell culture , interleukin 2 , antibody , messenger rna , microbiology and biotechnology , virology , immunology , immune system , virus , gene , biochemistry , genetics
We investigated the role of Interleukin‐6 (IL‐6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV‐2). Elevated levels of IL‐6 were found in serum of SRV‐2 antibody‐positive macaques, ascites from RF‐positive animals, and RF cell line culture media. IL‐6 mRNA levels increased approximately five‐fold in RF cells incubated with exogeneous SRV‐2. In RF cells, SRV‐2 functions to increase IL‐6 mRNA and protein production and presumably serves as autocrine growth factor.