Premium
Characterization of T‐ and B‐cell epitopes of a simian retrovirus (SRV‐2) envelope protein
Author(s) -
Malley A.,
Werner L.,
Benjamini E.,
Leung C.Y.,
Torres J.,
Pangares N.,
Shiigi S.,
Axthelm M.
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00515.x
Subject(s) - keyhole limpet hemocyanin , epitope , virology , peptide , biology , microbiology and biotechnology , retrovirus , antibody , viral envelope , virus , immunology , biochemistry
Synthetic envelope peptides of a simian retrovirus (SRV‐2) were used to define both T‐ and B‐cell epitopes of the envelope protein. The SRV‐2 peptide 100–106 specifically blocks rhesus anti‐SRV‐2 neutralizing antibody activity, and a peptide 100–106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV‐2 peptide 100–106 and 233–249 induces good T‐cell proliferation of murine spleen cells immunized with the SRV‐2 virus. Thus, SRV‐2 envelope peptide 100–106 represents both a T‐ and B‐cell epitope, and peptide 233–249 a T‐cell epitope.