Premium
Antibody‐dependent enhancement and neutralization pattern of sera from SIV‐infected or HIV‐2‐vaccinated rhesus monkeys
Author(s) -
Le Grand Roger,
Vogt Guillaume,
Chapel Alain,
Dormont Dominique
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00514.x
Subject(s) - virology , neutralization , antibody , neutralizing antibody , biology , simian immunodeficiency virus , vaccinia , recombinant dna , virus , in vitro , immunology , biochemistry , gene
Neutralizing and enhancing activities in sera were detected by using an in vitro infection assay of HUT 78 cells. Ten animals were vaccinated with HIV‐2ROD recombinant vaccinia viruses and respective purified proteins. Only sera from monkeys vaccinated with env elicited neutralizing antibodies. No antibody‐dependent enhancement (ADE) properties were detected in all the tested sera. Six other macaques were infected with SIV‐ mac251 . All of them had detectable ADE properties in their sera. No major neutralizing activity was detected.