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Early SIV encephalopathy
Author(s) -
Hurtrel Bruno,
Chakrabarti Lisa,
Hurtrel Maryse,
Maire Marie Annick,
Dormont Dominique,
Montagnier Luc
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00512.x
Subject(s) - in situ hybridization , pathology , encephalopathy , immunohistochemistry , giant cell , biology , inoculation , virology , medicine , messenger rna , biochemistry , gene
SIV encephalopathy was studied in rhesus macaques early after intracerebral (IC) or intravenous (IV) inoculation. Although SIV was detected in the brain of all IC‐inoculated animals, the CNS showed moderate neuropathological changes. IV‐inoculated animals presented a spectrum of brain changes ranging from perivascular infiltrates to multinucleated giant cells. CNS infection was detected as early as seven days post‐IV‐inoculation, mostly in a perivascular localization. Using combined immunohistochemistry and in situ hybridization, infected cells were shown to express macrophage markers.