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Severe autoimmune hemolytic anemia in SIV smm9 ‐infected Macaca mulatta
Author(s) -
Hillyer Christopher D.,
Brodie Anne R.,
Ansari Aftab A.,
Anderson Daniel C.,
McClure Harold M.
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00511.x
Subject(s) - reticulocytosis , autoimmune hemolytic anemia , hemolysis , immunology , spherocytosis , anemia , hemolytic anemia , haptoglobin , medicine , biology , virology , antibody , spleen , splenectomy
One of 15 rhesus macaques infected with SIV smm9 developed profound hemolysis with spherocytosis, reticulocytosis, and IgG and complement at the red blood cell surface. A female offspring born to this animal developed similar findings. Furthermore, cold agglutinins were noted in samples from both animals. Four of the 13 animals remaining in the cohort had weakly positive antiglobulin tests but were not anemic. Autoimmune hemolytic anemia may be an underrecognized cause of anemia in SIV infection.