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Endogenous bilirubin excretion in Bolivian squirrel monkeys with a Gilbert's‐like syndrome
Author(s) -
Myers Barbara A.,
Bruss Michael L.,
George Jeanne W.,
Cornelius Charles E.
Publication year - 1991
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1991.tb00499.x
Subject(s) - squirrel monkey , bilirubin , endogeny , excretion , endocrinology , medicine , biology , unconjugated hyperbilirubinemia , heme , physiology , chemistry , biochemistry , enzyme , anatomy
Fasted Bolivian squirrel monkeys (BoSM) exhibit a marked hyperbilirubinemia when compared to fed BoSM. This fasting hyperbilirubinemia (FH) is similar to that in human patients with Gilbert's syndrome. Endogenous bilirubin (BR) excretion (production) into bile was elevated two‐fold in BoSM upon fasting. The fraction of injected dose of 3 H‐aminolevulinic acid (ALA) incorporated into biliary BR in fasted monkeys was of less magnitude than in fed monkeys and was associated with lower specific activities of 3 H‐BR. Both the lower incorporation of ALA and lower specific activities of 3H‐BR in fasted BoSM suggest the increased BR excreted may have arisen from pre‐existing non‐labeled pools of either heme or BR.