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Increased Carbon Monoxide Excretion in Bolivian Squirrel Monkeys With Fasting Hyperbilirubinemia
Author(s) -
Rodgers P.A.,
Cornelius C.E.,
Vremany H.J.,
Tarkington B.K.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00455.x
Subject(s) - bilirubin , squirrel monkey , excretion , medicine , carbon monoxide , heme , endocrinology , heme oxygenase , respiration , biliverdin , chemistry , biology , biochemistry , enzyme , ecology , catalysis , anatomy
Pulmonary carbon monoxide (CO) excretion rates (VeCO) were 50% greater, on average, in Bolivian squirrel monkeys (BoSMs) which exhibit a unique fasting hyperbilirubinemia (FH), than in fasted control Brazilian squirrel monkeys (BrSMs). Since the catabolism of heme produces equimolar amounts of CO and bilirubin, the increased VeCOs are consistent with concurrent increases in endogenous bilirubin production rates. Tin‐protoporphyrin, a competitive inhibitor of heme oxygenase, significantly decreased both the VcCO and serum bilirubin level in fasted BoSMs. Overproduction of bilirubin may be responsible in part for the marked FH in BoSMs.